🔗 Share this article Depression Drug Adverse Reactions Such as Body Weight, BP Variations Vary Based on Pharmaceutical Recent research provides robust evidence of the extensive range of depression treatment adverse reactions. An extensive recent research determined that the unwanted effects of depression drugs vary considerably by drug. Certain pharmaceuticals resulted in reduced body weight, while different drugs led to weight gain. Pulse rate and arterial pressure also varied notably across drugs. Individuals encountering ongoing, severe, or worrisome unwanted effects must speak with a physician. Latest investigations has discovered that depression drug side effects may be more varied than earlier believed. This large-scale study, issued on the 21st of October, examined the effect of depression treatments on in excess of 58,000 subjects within the initial eight weeks of commencing therapy. These researchers analyzed 151 research projects of 30 drugs frequently employed to treat major depression. Although not every patient experiences side effects, certain of the most common noted in the study were variations in weight, arterial pressure, and metabolic markers. The study revealed notable variations among depression treatments. As an illustration, an 60-day treatment period of agomelatine was linked to an mean decrease in mass of about 2.4 kg (approximately 5.3 lbs), while another drug individuals added nearly 2 kg in the identical duration. Furthermore, marked variations in cardiovascular activity: one antidepressant tended to reduce pulse rate, while another medication raised it, creating a gap of around 21 beats per minute between the two medications. BP varied too, with an 11 millimeters of mercury disparity seen across one drug and another medication. Depression Drug Unwanted Effects Include a Broad Array Clinical professionals noted that the study's conclusions aren't new or startling to psychiatrists. "Clinicians have long recognized that distinct antidepressant medications range in their influences on body weight, BP, and additional metabolic indicators," one expert commented. "Nonetheless, what is significant about this study is the thorough, comparative measurement of these differences across a wide spectrum of bodily measurements using findings from over 58,000 individuals," this expert added. The investigation delivers robust evidence of the degree of unwanted effects, certain of which are more common than different reactions. Frequent depression drug side effects may encompass: gastrointestinal symptoms (nausea, diarrhea, constipation) intimacy issues (reduced sex drive, anorgasmia) weight changes (increase or reduction, based on the medication) sleep problems (insomnia or sedation) dry mouth, sweating, headache Additionally, rarer but medically important adverse reactions may encompass: rises in BP or cardiac rhythm (notably with serotonin-norepinephrine reuptake inhibitors and some tricyclic antidepressants) hyponatremia (notably in elderly individuals, with SSRIs and serotonin-norepinephrine reuptake inhibitors) liver enzyme elevations Corrected QT interval lengthening (potential of arrhythmia, especially with citalopram and some tricyclics) reduced emotions or lack of interest "A key factor to note here is that there are multiple varying categories of antidepressants, which contribute to the varying negative medication reactions," another specialist explained. "Moreover, depression treatments can affect each person differently, and negative reactions can differ according to the exact medication, amount, and individual elements including metabolism or comorbidities." While some side effects, such as changes in rest, appetite, or energy levels, are quite typical and frequently improve as time passes, others may be less frequent or continuing. Consult with Your Physician About Severe Adverse Reactions Depression drug side effects may range in intensity, which could require a change in your medication. "An adjustment in antidepressant medication may be warranted if the patient suffers persistent or unacceptable unwanted effects that don't get better with time or supportive measures," one professional said. "Additionally, if there is an emergence of recently developed health problems that may be exacerbated by the present medication, for example hypertension, abnormal heart rhythm, or significant mass addition." You may also think about talking with your physician regarding any absence of meaningful progress in depressive or anxiety-related symptoms following an sufficient testing period. An sufficient evaluation duration is typically 4–8 weeks' time at a effective dose. Individual choice is additionally important. Certain patients may choose to prevent specific side effects, including intimacy issues or {weight gain|increased body weight|mass addition